| 04.17 | FC Cincinnati | Nissan Stadium (Nashville, Tenn.) | T, 2-2 | Cádiz, Leal |
| 04.24 | Club de Foot Montréal | Nissan Stadium (Nashville, Tenn.) | T, 2-2 | Cádiz, Mukhtar |
| 05.02 | Inter Miami CF | Nissan Stadium (Nashville, Tenn.) | T, 0-0 | |
| 05.08 | New England Revolution | Nissan Stadium (Nashville, Tenn.) | W, 2-0 | Sapong, Muyl |
| 05.15 | Real Salt Lake | Rio Tinto Stadium (Sandy, Utah) | T, 0-0 | |
| 05.23 | Austin FC | Nissan Stadium (Nashville, Tenn.) | W, 1-0 | Leal |
| 05.29 | Atlanta United FC | Mercedes-Benz Stadium (Atlanta, Ga.) | T, 2-2 | Mukhtar (2) |
| 06.18 | New York Red Bulls | Red Bull Arena (Harrison, N.J.) | L, 0-2 | |
| 06.23 | Toronto FC | Nissan Stadium (Nashville, Tenn.) | W, 3-2 | Maher, Haakenson (2) |
| 06.26 | Club de Foot Montréal | Nissan Stadium (Nashville, Tenn.) | T, 1-1 | Danladi |
| 07.03 | Philadelphia Union | Nissan Stadium (Nashville, Tenn.) | W, 1-0 | Sapong |
| 07.08 | Atlanta United FC | Nissan Stadium (Nashville, Tenn.) | T, 2-2 | Anibaba, Mukhtar |
| 07.17 | Chicago Fire FC | Nissan Stadium (Nashville, Tenn.) | W, 5-1 | Mukhtar (3), Sapong, Anunga |
| 07.21 | Columbus Crew | Lower.com Field (Columbus, Ohio) | T, 0-0 | |
| 07.24 | FC Cincinnati | Nissan Stadium (Nashville, Tenn.) | W, 3-0 | Sapong (2), Leal |
| 08.01 | Toronto FC | BMO Field (Toronto, Ontario) | T, 1-1 | Castellanos |
| 08.04 | New England Revolution | Gillette Stadium (Foxborough, Mass.) | T, 0-0 | |
| 08.08 | Inter Miami CF | DRV PNK Stadium (Fort Lauderdale, Fla.) | L, 1-2 | Sapong |
| 08.15 | D.C. United | Nissan Stadium (Nashville, Tenn.) | W, 5-2 | Sapong (2), Mukhtar, Muyl (2) |
| 08.18 | Orlando City SC | Nissan Stadium (Nashville, Tenn.) | T, 1-1 | Sapong |
| 08.28 | Atlanta United FC | Mercedes-Benz Stadium (Atlanta, Ga.) | W, 2-0 | Ríos, Leal |
| 09.03 | New York City FC | Nissan Stadium (Nashville, Tenn.) | W, 3-1 | Mukhtar (2) |
| 09.11 | Club de Foot Montréal | Stade Saputo (Montréal, Quebec) | W, 1-0 | Zimmerman |
| 09.18 | Toronto FC | BMO Field (Toronto, Ontario) | L, 1-2 | Sapong |
| 09.22 | Inter Miami CF | DRV PNK Stadium (Fort Lauderdale, Fla.) | W, 5-1 | Mukhtar (2), Zimmerman, Leal, Johnston |
| 09.26 | Chicago Fire FC | Soldier Field (Chicago, Ill.) | T, 0-0 | |
| 09.29 | Orlando City SC | Nissan Stadium (Nashville, Tenn.) | T, 2-2 | Mukhtar, Leal |
| 10.03 | New York City FC | Red Bull Arena (Harrison, N.J.) | T, 0-0 | |
| 10.16 | D.C. United | Audi Field (Washington, D.C.) | T, 0-0 | |
| 10.20 | Columbus Crew | Nissan Stadium (Nashville, Tenn.) | T, 1-1 | Mukhtar |
| 10.23 | Philadelphia Union | Subaru Park (Chester, Pa.) | L, 0-1 | |
| 10.27 | FC Cincinnati | TQL Stadium (Cincinnati, Ohio) | W, 6-3 | Zimmerman, Leal (2), Sapong (2), Loba |
| 10.31 | Orlando City SC | Exploria Stadium (Orlando, Fla.) | T, 1-1 | Mukhtar |
| 11.07 | New York Red Bulls | Nissan Stadium (Nashville, Tenn.) | T, 1-1 | Mukhtar |