| 02.25 | New York City FC | GEODIS Park (Nashville, Tenn.) | W, 2-0 | Zimmerman, Shaffelburg |
| 03.04 | New York Red Bulls | Red Bull Arena (Harrison, N.J.) | T, 0-0 | |
| 03.11 | CF Montréal | GEODIS Park (Nashville, Tenn.) | W, 2-0 | Shaffelburg, Washington |
| 03.18 | New England Revolution | Gillette Stadium (Foxborough, Mass.) | L, 0-1 | |
| 03.25 | FC Cincinnati | GEODIS Park (Nashville, Tenn.) | L, 0-1 | |
| 04.01 | Orlando City SC | Exploria Stadium (Orlando, Fla.) | W, 2-0 | Picault, Mukhtar |
| 04.08 | Toronto FC | GEODIS Park (Nashville, Tenn.) | T, 0-0 | |
| 04.15 | New York City FC | Citi Field (New York City, N.Y.) | L, 1-2 | Mukhtar |
| 04.22 | Los Angeles FC | GEODIS Park (Nashville, Tenn.) | T, 1-1 | Mukhtar |
| 04.29 | Atlanta United FC | GEODIS Park (Nashville, Tenn.) | W, 3-1 | Picault, Bunbury, Shaffelburg |
| 05.06 | Chicago Fire FC | GEODIS Park (Nashville, Tenn.) | W, 3-0 | Mukhtar (3) |
| 05.13 | D.C. United | Audi Field (Washington, D.C.) | T, 1-1 | Muyl |
| 05.17 | Inter Miami CF | GEODIS Park (Nashville, Tenn.) | W, 2-1 | Picault, MacNaughton |
| 05.20 | Charlotte FC | Bank of America Stadium (Charlotte, N.C.) | W, 2-1 | Mukhtar (2) |
| 05.28 | Columbus Crew | GEODIS Park (Nashville, Tenn.) | W, 3-1 | Picault, Bunbury, Mukhtar |
| 06.03 | FC Dallas | Toyota Stadium (Frisco, Texas) | W, 2-1 | Mukhtar |
| 06.10 | Toronto FC | BMO Field (Toronto, Ontario) | T, 1-1 | Leal |
| 06.17 | St. Louis CITY SC | GEODIS Park (Nashville, Tenn.) | W, 3-1 | Mukhtar (3) |
| 06.21 | CF Montréal | Saputo Stadium (Montreal, Quebec) | L, 0-1 | |
| 06.24 | Columbus Crew | Lower.com Field (Columbus, Ohio) | L, 0-2 | |
| 07.01 | D.C. United | GEODIS Park (Nashville, Tenn.) | W, 2-0 | Leal (2) |
| 07.08 | Chicago Fire FC | Soldier Field (Chicago, Ill.) | L, 0-1 | |
| 07.12 | Philadelphia Union | GEODIS Park (Nashville, Tenn.) | L, 0-2 | |
| 07.15 | FC Cincinnati | TQL Stadium (Cincinnati, Ohio) | L, 1-3 | Zimmerman |
| 08.26 | Atlanta United FC | Mercedes-Benz Stadium (Atlanta, Ga.) | L, 0-4 | |
| 08.30 | Inter Miami CF | DRV PNK Stadium (Fort Lauderdale, Fla.) | T, 0-0 | |
| 09.02 | Charlotte FC | GEODIS Park (Nashville, Tenn.) | T, 1-1 | Mukhtar |
| 09.20 | Sporting Kansas City | Children's Mercy Park (Kansas City, Kan.) | W, 3-0 | Picault, Mukhtar, Maher |
| 09.23 | San Jose Earthquakes | PayPal Park (San Jose, Calif.) | T, 1-1 | Bunbury |
| 09.30 | Seattle Sounders FC | GEODIS Park (Nashville, Tenn.) | T, 0-0 | |
| 10.04 | Orlando City SC | GEODIS Park (Nashville, Tenn.) | L, 0-1 | |
| 10.07 | Philadelphia Union | Subaru Park (Chester Park) | T, 0-0 | |
| 10.14 | New England Revolution | GEODIS Park (Nashville, Tenn.) | W, 3-2 | McCarty, Surridge (2) |
| 10.21 | New York Red Bulls | GEODIS Park (Nashville, Tenn.) | L, 0-1 | |