| 03.09 | Loudoun United FC | First Tennessee Park (Nashville, Tenn.) | W, 2-0 | Lancaster, Ríos |
| 03.16 | Saint Louis FC | First Tennessee Park (Nashville, Tenn.) | L, 0-1 | |
| 03.24 | New York Red Bulls II | MSU Soccer Park (Montclair, N.J.) | T, 1-1 | Ríos |
| 04.06 | Ottawa Fury FC | TD Place Stadium (Ottawa, Ontario) | W, 3-0 | Ríos (2), Hume |
| 04.13 | Memphis 901 FC | First Tennessee Park (Nashville, Tenn.) | W, 2-0 | LaGrassa, Mensah |
| 04.20 | Charleston Battery | MUSC Health Stadium (Charleston, S.C.) | L, 1-3 | Ríos |
| 04.27 | Pittsburgh Riverhounds SC | Highmark Stadium (Pittsburgh, Pa.) | T, 2-2 | Tribbett, Bourgeois |
| 05.04 | Atlanta United 2 | Fifth Third Bank Stadium (Kennesaw, Ga.) | W, 2-0 | LaGrassa |
| 05.08 | Tampa Bay Rowdies | First Tennessee Park (Nashville, Tenn.) | L, 0-1 | |
| 05.11 | Swope Park Rangers | First Tennessee Park (Nashville, Tenn.) | W, 5-1 | Ríos (2), Winn, Belmar, Lancaster |
| 05.18 | Charlotte Independence | First Tennessee Park (Nashville, Tenn.) | T, 1-1 | Moloto |
| 05.22 | Birmingham Legion FC | BBVA Compass Field | W, 1-0 | Ríos |
| 05.25 | Indy Eleven | Lucas Oil Stadium | T, 0-0 | |
| 06.09 | Bethlehem Steel FC | McCarthy Stadium (Philadelphia, Pa.) | W, 4-1 | Tribbett, Mensah, Kimura, Lancaster |
| 06.16 | Hartford Athletic | Rentschler Field (Hartford, Conn.) | W, 3-2 | Ríos, Moloto, Lancaster |
| 06.22 | Ottawa Fury FC | First Tennessee Park (Nashville, Tenn.) | T, 3-3 | Ríos, Mensah, Lancaster |
| 06.29 | North Carolina FC | Sahlen’s Stadium at WakeMed Soccer Park (Cary, N.C.) | L, 0-1 | |
| 07.06 | Louisville City FC | Louisville Slugger Field (Louisville, Ky.) | L, 1-2 | Ríos |
| 07.17 | Memphis 901 FC | AutoZone Park (Memphis, Tenn.) | W, 2-0 | Ockford, Ríos |
| 07.27 | Indy Eleven | Nissan Stadium (Nashville, Tenn.) | W, 2-0 | Ríos, Winn |
| 08.03 | Swope Park Rangers | Children’s Mercy Park (Kansas City, Kan.) | W, 2-0 | Ríos, Moloto |
| 08.07 | Hartford Athletic | First Tennessee Park (Nashville, Tenn.) | W, 4-0 | Tribbett, Ríos, Winn |
| 08.10 | Bethlehem Steel FC | First Tennessee Park (Nashville, Tenn.) | T, 0-0 | |
| 08.17 | Charlotte Independence | Sportsplex at Matthews (Matthews, N.C.) | W, 3-1 | Ríos (2), Belmar |
| 08.21 | New York Red Bulls II | First Tennessee Park (Nashville, Tenn.) | L, 1-2 | Tribbett |
| 08.24 | Charleston Battery | First Tennessee Park (Nashville, Tenn.) | W, 2-1 | Mensah, Akinyode |
| 08.31 | Tampa Bay Rowdies | Al Lang Stadium (St. Petersburg, Fla.) | W, 2-1 | Moloto, Belmar |
| 09.07 | Saint Louis FC | West Community Stadium (Fenton, Mo.) | L, 0-1 | |
| 09.17 | Birmingham Legion FC | First Tennessee Park (Nashville, Tenn.) | W, 1-0 | |
| 09.21 | Pittsburgh Riverhounds SC | First Tennessee Park (Nashville, Tenn.) | T, 0-0 | |
| 09.28 | Loudoun United FC | Segra Field (Leesburg, Va.) | W, 2-0 | Ríos, Mensah |
| 10.08 | Louisville City FC | First Tennessee Park (Nashville, Tenn.) | W, 2-1 | Washington, Ockford |
| 10.12 | North Carolina FC | Nissan Stadium (Nashville, Tenn.) | W, 2-0 | Mensah, Moloto |
| 10.19 | Atlanta United 2 | First Tennessee Park (Nashville, Tenn.) | W, 3-0 | Ríos (2), Lasso |